Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

Expanding nature's chemical repertoire through metabolic engineering and biocatalysis.

Dr Ben Shen is a Professor in the Departments of Chemistry and Molecular Therapeutics and the Director of the Natural Products Library Initiative at the Scripps Research Institute. Before joining Scripps Florida, Dr Shen was a faculty member in the School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison (2001–2010) and in the Department of Chemistry, University of Califo...

Whey upgrading by enzyme biocatalysis

Whey is a co-product of processes for the production of cheese and casein that retains most of the lactose content in milk. World production of whey is estimated around 200 million tons per year with an increase rate of about 2%/per year. Milk production is seasonal, so surplus whey is unavoidable. Traditionally, whey producers have considered it as a nuisance and strategies of whey handling ha...

Expanding the Scope of Protein Science and Engineering with Noncanonical Amino Acids

Noncanonical amino acids (ncAAs) have the potential to greatly expand the chemical functionalities available within proteins. Methodologies for the genetic encoding and incorporation of ncAAs into proteins using the protein synthesis machinery from living organisms are now quite common, and applications of proteins containing ncAAs are emerging in a variety of fields. In this review, we highlig...

: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes

هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...

Expanding the Scope of Dishonesty